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Ok. So now its time for a quick summary and definition of Non-Aqueous-Phase. Wohlschlag, C. nonaqueous phase synthesis pdf download. Doepke, C.W. Evolution of Biotechnology and the Rise of Chemistry. They concluded:. and was the most frequently used product for dis­equilibrium experiments in water since the first desalination plant was built in 1961. xi). These new strategies allowed organic compounds to be synthesized in water. As an environmentally compatible reaction medium, water could allow organic synthesis that would have failed in organic solvents. Yields typically reach about 50% by volume and consist of a mixture of organic compounds. fragment reagents for nonaqueous-phase-transitions pdf Introduction {#Sec1} ============ The chapter will begin with an overview of the basic principles of organic synthesis. It will then focus on the principles and tools for studying nonaqueous reactions and reactions in water. Both classically developed reagents as well as more modern reagents and methods will be discussed. Introduction {#Sec2} ============ Organic synthesis is the art of making small molecules and macromolecules. Two categories exist: the classical and the modern. In many cases the differences in the synthesis is only superficial because both approaches rely on the same reagents and principles. Traditional organic synthesis in the 20^th^ century employs solvents such as benzene, toluene and chloro­form. However, these solvents pose serious drawbacks. The use of solvents such as benzene is undesirable because it is both flammable and a carcinogen. The undesirability of non-aqueous reactions using tetrahydro-2*H*-1,2,3-thiadiazine-5-thione (tet) (which is abbreviated as THT) is greater than the use of benzene. It is therefore important to find a safer alternative to benzene. Water is more environmentally friendly than traditional solvents, and therefore represents a great possibility for the development of new chemical processes. However, there are several factors that hinder the use of water as a solvent. These factors include the fact that most of the organic reactions are performed in organic solvents and that water is a poor solvent for many organic compounds. This is mainly due to the low polarity of many organic compounds. Another reason for poor

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